Influence of narrowband UVB irradiation

Type:Uv phototherapy Time:2014-11-17 15:00:51

Influence of narrowband UVB irradiation of serum on autologous serum skin test results.

Kaçar N1, Taşli L, Sanlı B, Topsakal M.

Author information

Erratum in

Int J Dermatol. 2013 Oct;52(10):1293. Kaar, Nida [corrected to Kaçar, Nida].

Abstract

BACKGROUND:

Autologous serum skin test (ASST) is an in vivo test to demonstrate circulating endogenous proinflammatory or wheal-inducing

factors in urticaria patients. While ASST was negative in a patient with solar urticaria and in a patient with localized heat

urticaria, test results turned to positive when performed with visible light-irradiated and heated serums, respectively.

These data suggest that some factors and/or antibodies in serum may be activated or inhibited with different factors. We

aimed to investigate whether or not ASST results change when performed with narrowband ultraviolet B (UVB)-irradiated serum.

MATERIALS AND METHODS:

Seventy-seven patients with chronic idiopathic urticaria underwent ASST twice in consecutive days. The second ASST was

performed with narrowband UVB-irradiated serum. The results of the first and second ASSTs were compared.

RESULTS:

The first ASST results were positive in 46 (59.7%) patients. ASST results reversed oppositely in 36 (46.8%) patients, turned

from negative to positive in 19 patients, and turned from positive to negative in 17 patients when performed with narrowband

UVB-irradiated serum.

CONCLUSION:

Our results suggest that narrowband UVB may have modifying effects on some wheal-inducing factors and/or antibodies. On which

factors in serum narrowband UVB has effects may be investigated.

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